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Chemical Name:Valsartan benzyl ester
CAS.NO:137863-20-8
Synonyms:Valsartan benzyl ester;L-Valine, N-(1-oxopentyl)-N-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-, phenylmethyl ester;Benzyl N-pentanoyl-N-{[2′-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-L-valinate;benzyl (2S)-3-methyl-2-[pentanoyl-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]amino]butanoate;T5MNNNJ ER BR D1NV4&YVO1R&Y1&1 &&L or S Form;Phenylmethyl N-(1-oxopentyl)-N-[[2′-(1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-L-valinate;Benzyl N-pentanoyl-N-{[2′-(2H-tetrazol-5-yl)-4-biphenylyl]methyl}-L-valinate;Benzyl N-pentanoyl-N-{[2′-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-L-valinate;Valsartan Impurity 2
Molecular Formula:C31H35N5O3
Molecular Weight:525.641
HS Code:
Physical and Chemical Properties:
Melting point:N/A
Boiling point:720.1±70.0 °C at 760 mmHg
Density:1.2±0.1 g/cm3
Index of Refraction:1.589
PSA:101.07000
Exact Mass:525.273987
LogP:7.16
Material Safety Information (Applicable for Hazard Chemicals)
RIDADR:
Packing Group:
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“This means that UCLA will now be able to begin the process of applying to the Food and Drug Administration for permission to start an expanded use protocol to treat patients,” CIRM CEO Maria Millan said in a May 28 statement.
UCLA scientist Donald Kohn, who developed the therapy, told the Los Angeles Times that he will start the FDA process for compassionate use as soon as possible. UCLA and UCL will also seek a new commercial partner, Kohn said.
Coyle replaced former CEO Kevin King, who was with the company for nine years, having previously worked for Medtronic as the executive vice president and president of the cardiovascular portfolio. Coyle said shortly after taking over that his international experience with Medtronic will help iRhythm as the company expands into new markets.
However, Coyle’s brief tenure was defined by the Medicare pricing saga with Novitas Solutions, a Medicare Administrative Contractor.
After CMS did not set a national price for long-term cardiac monitoring last December, the decision for price-setting was then passed on to the MACs.
Novitas originally posted rates for extended cardiac monitoring between $40-$50 in late January, well below the historical $311 range.
The drastically cut rates shook industry and Wall Street analysts, and the company’s stock price dropped by nearly 33% the day of the announcement.
During his first earnings call in February, Coyle said that iRhythm met with Novitas to talk about different pricing methodologies. However, Coyle was unable to say when, or if, any changes would be made.
The pricing challenges created uncertainty for a market that Wall Street analysts were consistently bullish on amid a trend of growing wearables use.
The space even saw a flurry of deals where nearly all of iRhythm’s competition was bought up by large medtechs like Philips and Boston Scientific.
Novitas ultimately set rates for shorter-term and longer-term cardiac monitoring at $103 and $115 in April, respectively, approximately one-third of historical rates.
Coyle said on a company call that the new rates were below the costs to provide the services and higher rates would need to be set, either through another Novitas adjustment or, once again, trying to get national pricing through CMS.
Throughout the Novitas saga, iRhythm’s stock price dropped from $252.65 Jan. 29 to $62 when the market opened Wednesday.
iRhythm said Coyle’s decision to resign will not impact the reimbursement strategy going forward — the company will still pursue higher rates through Novitas, other MACs and CMS.
Analysts were surprised by Coyle’s resignation.
Truist Securities analysts wrote that during a call with iRhythm management following the announcement, the company “made clear multiple times in our conversation that there have not been any notable developments since its earnings call (which was held in early May) related to reimbursement. Aconitane-8,10,11-triol, 1,6,19-trimethoxy-4-(methoxymethyl)-16-methyl-, 8-acetate 10-benzoate, (1.α.,6.α.,10.α.,19.β.) vendor & factory.
“This means that UCLA will now be able to begin the process of applying to the Food and Drug Administration for permission to start an expanded use protocol to treat patients,” CIRM CEO Maria Millan said in a May 28 statement.
UCLA scientist Donald Kohn, who developed the therapy, told the Los Angeles Times that he will start the FDA process for compassionate use as soon as possible. UCLA and UCL will also seek a new commercial partner, Kohn said.
Coyle replaced former CEO Kevin King, who was with the company for nine years, having previously worked for Medtronic as the executive vice president and president of the cardiovascular portfolio. Coyle said shortly after taking over that his international experience with Medtronic will help iRhythm as the company expands into new markets.
However, Coyle’s brief tenure was defined by the Medicare pricing saga with Novitas Solutions, a Medicare Administrative Contractor.
After CMS did not set a national price for long-term cardiac monitoring last December, the decision for price-setting was then passed on to the MACs.
Novitas originally posted rates for extended cardiac monitoring between $40-$50 in late January, well below the historical $311 range.
The drastically cut rates shook industry and Wall Street analysts, and the company’s stock price dropped by nearly 33% the day of the announcement.
During his first earnings call in February, Coyle said that iRhythm met with Novitas to talk about different pricing methodologies. However, Coyle was unable to say when, or if, any changes would be made.
The pricing challenges created uncertainty for a market that Wall Street analysts were consistently bullish on amid a trend of growing wearables use.
The space even saw a flurry of deals where nearly all of iRhythm’s competition was bought up by large medtechs like Philips and Boston Scientific.
Novitas ultimately set rates for shorter-term and longer-term cardiac monitoring at $103 and $115 in April, respectively, approximately one-third of historical rates.
Coyle said on a company call that the new rates were below the costs to provide the services and higher rates would need to be set, either through another Novitas adjustment or, once again, trying to get national pricing through CMS.
Throughout the Novitas saga, iRhythm’s stock price dropped from $252.65 Jan. 29 to $62 when the market opened Wednesday.
iRhythm said Coyle’s decision to resign will not impact the reimbursement strategy going forward — the company will still pursue higher rates through Novitas, other MACs and CMS.
Analysts were surprised by Coyle’s resignation.
Truist Securities analysts wrote that during a call with iRhythm management following the announcement, the company “made clear multiple times in our conversation that there have not been any notable developments since its earnings call (which was held in early May) related to reimbursement. Aconitane-8,10,11-triol, 1,6,19-trimethoxy-4-(methoxymethyl)-16-methyl-, 8-acetate 10-benzoate, (1.α.,6.α.,10.α.,19.β.) vendor & factory.
