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Product Description:
Product Name: Lamotrigine CAS NO: 84057-84-1
Synonyms:
HYDROXYMETHYL PROGESTERONE;
6-O-TRITYL-1,2,3,4-TETRA-O-ACETYL-ALPHA-D-MANNOPYRANOSE;
1,2,4-TRIAZINE-3,5-DIAMINE,6-(2,3-DICHLOROPHENYL)-;
Chemical & Physical Properties:
Appearance: White crystallization
Assay :≥99.00%
Density: 1.572 g/cm3
Boiling Point: 503.1℃ at 760 mmHg
Melting Point: 177-181℃
Flash Point: 258.1℃
Stability: Stable at normal temperatures and pressures.
Storage Condition: 2-8℃
Safety Information:
RTECS: XY5850700
Hazard Class: 6.1(b)
Safety Statements: S45-36-26
HS Code: 2933699090
Packing Group: III
WGK Germany: 3
RIDADR: UN 2811 6
Risk Statement: R25
Hazard Code: T
An anticonvulsant. Inhibits glutamate release, possible through inhibition of Sodium, Potassium and Calcium currents. Used in treatment of bipolar depression. Lamotrigine(BW430C) is a novel anticonvulsant drug for inhibition of 5-HT and sodium channelTarget: Sodium ChannelLamotrigine stabilises presynaptic neuronal membranes by blockade of voltage-dependent sodium channels, thus preventing the release of excitatory neurotransmitters, particularly glutamate and aspartate. In rat cerebral cortex tissue incubated with veratrine 10 mg/L, lamotrigine is twice as potent in inhibiting the release of glutamate and aspartate (ED 50 = 5.38 mg/L for each) than the release of GABA (ED50 = 11.2 mg/L), and is much less potent in inhibiting acetylcholine release (ED50 = 25.6 mg/L) when cortical slices is exposed to veratrine 75 mg/L. Basal glutamate release is unaffected. Lamotrigine inhibits high-frequency sustained repetitive firing of sodium-dependent action potentials, indicating a direct effect on voltage-activated sodium channels. Lamotrigine (Lamictal), a phenyltriazine derivative, is a well established anticonvulsant agent that has shown efficacy in the prevention of mood episodes in adult patients with bipolar I disorder. lamotrigine significantly delayed time to intervention for a depressive episode and showed limited efficacy in delaying time to intervention for a manic/hypomanic episode, compared with placebo. Lamotrigine is generally well tolerated .
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