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Product Description:
Product Name: Penfluridol CAS NO: 26864-56-2
Synonyms:
1-[4,4-Bis(p-fluorophenyl)butyl]-4-(4-chloro-alpha,alpha,alpha-trifluoro-m-tolyl)-4-piperidinol;
4-Piperidinol, 1-[4,4-bis(4-fluorophenyl)butyl]-4-[4-chloro-3-(trifluoromethyl)phenyl]-;
4-Piperidinol, 4-(4-chloro-alpha,alpha,alpha-trifluoro-m-tolyl)-1-(4,4-bis(p-fluorophenyl)butyl)-;
Chemical & Physical Properties:
Appearance: Off-white to white crystalline powder
Assay :≥99.0%
Density: 1.29 g/cm3
Boiling Point: 587.7℃ at 760 mmHg
Melting Point: 105-107℃
Flash Point: 309.2℃
Refractive Index: 1.552
Stability: Stable at normal temperatures and pressures.
Storage Condition: 2-8℃
Vapor Pressure: 1.17E-14mmHg at 25℃
Safety Information:
RTECS: TN6957000
Hazard Class: 6.1
Safety Statement: S45
HS Code: 2942000000
WGK Germany: 3
RIDADR: UN 2811
Risk Statement: R25
Hazard Code: T
Hazard Declaration: H301
Symbol: GHS06
Signal Word: Danger
Caution Statement: P301 + P310
Penfluridol (Semap, Micefal, Longoperidol) is a highly potent, first generation diphenylbutylpiperidine antipsychotic. It was discovered at Janssen Pharmaceutica in 1968. Related to other diphenylbutylpiperidine antipsychotics, pimozide and fluspirilene, penfluridol has an extremely long elimination half-life and its effects last for many days after single oral dose. Its antipsychotic potency, in terms of dose needed to produce comparable effects, is similar to both haloperidol and pimozide. It is only slightly sedative, but often causes extrapyramidal side-effects, such as akathisia, dyskinesiae and pseudo-Parkinsonism. Penfluridol is indicated for antipsychotic treatment of chronic schizophrenia and similar psychotic disorders, it is, however, like most typical antipsychotics, being increasingly replaced by the atypical antipsychotics. Due to its extremely long-lasting effects, it is often prescribed to be taken orally as tablets only once a week (q 7 days). The once-weekly dose is usually 10–60mg.
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