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Chemical Name:8-Fluoro-4-hydroxyquinoline-3-carboxylic Acid
CAS.NO:63010-70-8
Synonyms:8-Fluoro-4-hydroxyquinoline-3-carboxylic acid;3-Quinolinecarboxylic acid, 8-fluoro-4-hydroxy-;8-Fluoro-4-hydroxy-3-quinolinecarboxylic acid;8-fluoro-4-oxo-1H-quinoline-3-carboxylic acid;8-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
Molecular Formula:C10H6FNO3
Molecular Weight:207.158
HS Code:2933499090
Physical and Chemical Properties:
Melting point:N/A
Boiling point:387.8±42.0 °C at 760 mmHg
Density:1.6±0.1 g/cm3
Index of Refraction:1.700
PSA:70.42000
Exact Mass:207.033173
LogP:3.55
Material Safety Information (Applicable for Hazard Chemicals)
RIDADR:
Packing Group:
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Related News: The main API products include antihypertensive, psychotropic and anti-AIDS special APIs. Antihypertensive APIs are mainly pulic and sartan drugs, and they are the world’s major suppliers of pulic and sartan APIs. 8-Fluoro-4-hydroxyquinoline-3-carboxylic Acid manufacturer Prime Minister Scott Morrison said Saturday that all travelers from mainland China allowed into Australia had to be quarantined for 14 days. 8-Fluoro-4-hydroxyquinoline-3-carboxylic Acid supplier He pointed out that Taiwan had 10 confirmed cases, versus more than 14,000 in mainland China. 8-Fluoro-4-hydroxyquinoline-3-carboxylic Acid vendor Dr. Anthony Fauci, director of the U.S. National Institute of Allergy and Infectious Diseases, said, It’s really very impressive,” noting that the vaccine was as good as the most effective shots developed so far during the pandemic. “It’s very important for the world’s population to have, yet again, another highly efficacious vaccine that looks in its trial to have a good safety profile,” Fauci told the Washington Post.
As heartening as the results were, the vaccine may not become a key player in the pandemic until late summer or fall.
Erck told the Post that Novavax will apply for regulatory clearance from a half-dozen countries in the third quarter, which begins in July. With tens of millions of doses already in hand, the company plans to boost manufacturing to produce 100 million doses a month by the end of September and 150 million doses a month in the last three months of the year.
In the United States, the company still needs to file for emergency authorization. The data, which was presented in a news release, will be examined by regulators at the U.S. Food and Drug Administration and by an advisory committee of vaccine advisers. Erck said the vaccine will likely have its biggest initial impact globally, through the World Health Organization’s COVAX initiative.
“A lot of our vaccine is going to be targeted in the early stages for COVAX … and so a lot of those doses are going to get into the low- and middle-income countries first, which is a good thing,” Erck said. Novavax has pledged 1.1 billion doses to COVAX.
The Novavax vaccine was one of six candidates the U.S. government made a huge bet on, investing $1.6 billion to pay for research and development and preordering 110 million doses, the Post reported.
In January, a large U.K. trial showed it was nearly 90% effective, even once a more transmissible variant had taken hold. Over the past five months, health officials and scientists have waited anxiously for confirming evidence from the U.S. trial. But that second study did not start until the end of December, due in part to manufacturing delays.
Meanwhile, the United States had secured more than enough shots from the three companies with authorized vaccines — Pfizer, Moderna and Johnson & Johnson — to satisfy demand. A fourth, from AstraZeneca, reported results in March.
Recombinant protein vaccines such as Novavax’s — the hepatitis B vaccine is another example — teach the immune system to recognize a virus by introducing a lab-made version of a viral protein.
Once the production process is in place, the vaccine offers potential advantages.
“The benefit of their formulation … is it’s remarkably scalable, so they can scale to a very high number of doses,” Matthew Frieman, a coronavirus expert at the University of Maryland’s School of Medicine who has worked with the company in the past, told the Post. “It’s not a super-strange production platform … you don’t need super-specialized facilities. It’s stable, so you don’t need a severe cold chain” to store the vaccine, he said.
The American South and Midwest are home to the highest obesity rates in the nation, but a new study reveals that severely obese residents of those regions are the least likely to choose lifesaving weight-loss surgery.
“Bariatric surgery has been shown to provide long-term weight loss, sustained improvements in cardiovascular and metabolic health, and even prolonged longevity,” noted study author Dr. Scott Schimpke, but the analysis “shows we continue to underutilize the best treatment for morbid obesity and associated metabolic syndrome. 8-Fluoro-4-hydroxyquinoline-3-carboxylic Acid factory TSA notified airlines Saturday about the restrictions. CNN is reaching out to TSA for comment.
As heartening as the results were, the vaccine may not become a key player in the pandemic until late summer or fall.
Erck told the Post that Novavax will apply for regulatory clearance from a half-dozen countries in the third quarter, which begins in July. With tens of millions of doses already in hand, the company plans to boost manufacturing to produce 100 million doses a month by the end of September and 150 million doses a month in the last three months of the year.
In the United States, the company still needs to file for emergency authorization. The data, which was presented in a news release, will be examined by regulators at the U.S. Food and Drug Administration and by an advisory committee of vaccine advisers. Erck said the vaccine will likely have its biggest initial impact globally, through the World Health Organization’s COVAX initiative.
“A lot of our vaccine is going to be targeted in the early stages for COVAX … and so a lot of those doses are going to get into the low- and middle-income countries first, which is a good thing,” Erck said. Novavax has pledged 1.1 billion doses to COVAX.
The Novavax vaccine was one of six candidates the U.S. government made a huge bet on, investing $1.6 billion to pay for research and development and preordering 110 million doses, the Post reported.
In January, a large U.K. trial showed it was nearly 90% effective, even once a more transmissible variant had taken hold. Over the past five months, health officials and scientists have waited anxiously for confirming evidence from the U.S. trial. But that second study did not start until the end of December, due in part to manufacturing delays.
Meanwhile, the United States had secured more than enough shots from the three companies with authorized vaccines — Pfizer, Moderna and Johnson & Johnson — to satisfy demand. A fourth, from AstraZeneca, reported results in March.
Recombinant protein vaccines such as Novavax’s — the hepatitis B vaccine is another example — teach the immune system to recognize a virus by introducing a lab-made version of a viral protein.
Once the production process is in place, the vaccine offers potential advantages.
“The benefit of their formulation … is it’s remarkably scalable, so they can scale to a very high number of doses,” Matthew Frieman, a coronavirus expert at the University of Maryland’s School of Medicine who has worked with the company in the past, told the Post. “It’s not a super-strange production platform … you don’t need super-specialized facilities. It’s stable, so you don’t need a severe cold chain” to store the vaccine, he said.
The American South and Midwest are home to the highest obesity rates in the nation, but a new study reveals that severely obese residents of those regions are the least likely to choose lifesaving weight-loss surgery.
“Bariatric surgery has been shown to provide long-term weight loss, sustained improvements in cardiovascular and metabolic health, and even prolonged longevity,” noted study author Dr. Scott Schimpke, but the analysis “shows we continue to underutilize the best treatment for morbid obesity and associated metabolic syndrome. 8-Fluoro-4-hydroxyquinoline-3-carboxylic Acid factory TSA notified airlines Saturday about the restrictions. CNN is reaching out to TSA for comment.
