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Product Description:
Product Name: Nicergoline CAS NO: 27848-84-6
Synonyms:
5-bromo-nicotinic acid 10-methoxy-1,6-dimethyl-ergolin-8-ylmethyl ester;
ergoline-8-methanol 10-methoxy-1,6-dimethyl-,8-(5-bromo-3-pyridinecarboxylate);
[(8R,10S)-10-Methoxy-1,6-dimethylergolin-8-yl]methyl 5-Bromopyridine-3-carboxylate;
Chemical & Physical Properties:
Appearance: White or yellowish powder
Assay :≥99.00%
Density: 1.47 g/cm3
Boiling Point: 594.4℃ at 760 mmHg
Flash Point: 313.3℃
Stability: Stable at normal temperatures and pressures.
Water Solubility: Soluble in alcohol, chloroform, and acetone. Insoluble in water.
Storage Condition: 2-8℃
Vapor Pressure: 0mmHg at 25℃
Safety Information:
Hazard Class: 6.1(b)
Safety Statement: S36
Packing Group: III
RIDADR: UN 1544
Risk Statement: R22
Hazard Code: Xn
Nicergoline (INN, marketed under the trade name Sermion) is an ergot derivative used to treat senile dementia and other disorders with vascular origins. It has been found to increase mental agility and enhance clarity and perception. It decreases vascular resistance and increases arterial blood flow in the brain, improving the utilization of oxygen and glucose by brain cells. It has similar vasoactive properties in other areas of the body, particularly the lungs.
It is used for vascular disorders such as cerebral thrombosis and atherosclerosis, arterial blockages in the limbs, Raynaud”s disease, vascular migraines, and retinopathy.
Nicergoline has been registered in over fifty countries and has been used for more than three decades for the treatment of cognitive, affective, and behavioral disorders of older people.
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