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Product Description:
Product Name: Rucaparib CAS NO: 283173-50-2
Synonyms:
6H-Pyrrolo[4,3,2-ef][2]benzazepin-6-one,8-fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl];
UNII-8237F3U7EH;
8-fluoro-2-(4-methylaminomethyl-phenyl)-1,3,4,5-tetrahydro-azepino[5,4,3-cd]indol-6-one;
Chemical & Physical Properties:
Appearance: Yellow solid
Assay :≥99.0%
Density: 1.281 g/cm3
Boiling Point: 625.248℃ at 760 mmHg
Flash Point: 331.938℃
Storage temp.: Keep in dark place,Sealed in dry,2-8℃
Vapour Pressure: 0.0±1.8 mmHg at 25℃
Index of Refraction: 1.649
Safety Information:
HS Code: 2933990090
Rucaparib (AG 014699) is a PARP inhibitor being investigated as a potential anti-cancer agent. Rucaparib is the first-in-class clinical candidate targeting the DNA repair enzyme poly-ADPribose polymerase-1 (PARP-1), and was first synthesised as part of a collaboration between scientists working in Northern Institute of Cancer Research and Medical School of Newcastle University, alongside Agouron Pharmaceuticals (San Diego). It is being developed by Clovis Oncology.
Rucaparib inhibits ”the contraction of isolated vascular smooth muscle, including that from the tumours of cancer patients. It also reduces the migration of some cancer and normal cells in culture.”; It can be taken orally in tablet form.
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