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Tetrahydrozoline Hydrochloride
2-(1,2,3,4-tetrahydronaphthalen-1-yl)-4,5-dihydro-1H-imidazole,hydrochloride
Appearance and properties: off-white solid
Boiling point: 393.5ºC at 760 mmHg
Melting point: 197 °C
Flash point: 191.8ºC
Storage conditions: Refrigerator
Uses: Tetrahydrozoline hydrochloride is an α-adrenergic receptor agonist.
| Items of Analysis | Standard of Analysis | Test Results |
| Appearance | White to off-white powder | Conforms |
| Identification | IR spectrum UV spectrum Reaction of Chlorides |
Conforms Conforms Positive |
| Heavy metals(USP) | NMT 0.005% | ＜0.005% |
| Loss on drying(USP) | NMT 1.0% | 0.2% |
| Residue on ignition | NMT 0.1% | ＜0.1% |
| Related substances-sum: -TLC(USP) -HPLC |
NMT 2.0% NMT 1.0% |
＜2.0% 0.8% |
| Assay(in the dried substance): -titration(USP) |
98.0-100.5% | 99.7% |
| Residual solvents: -Methanol -Ethanol -Acetonitrile -Toluene |
NMT 3000ppm NMT 5000ppm NMT 410ppm NMT 890ppm |
Not detected Conforms Not detected Not detected |
| Conclusion | Conforms to USP 39 | |
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