(Z)-Guggulsterone | CAS:95975-55-6 99.0% bulk supply

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CAS No: 95975-55-6

Product Name: (Z)-Guggulsterone

Other Name:

(Z)-Guggulsterone

Cis-Guggulsterone

(17Z)-Pregna-4,17-diene-3,16-dione

4,17(20)-Z-pregnadiene-3,16-dione

Density: 1.1±0.1 g/cm3

Boiling Point: 463.3±45.0 °C at 760 mmHg

Molecular Formula: C21H28O2

Molecular Weight: 312.446

Flash Point: 172.3±25.7 °C

Exact Mass: 312.208923

PSA: 34.14000

LogP: 3.65

Vapour Pressure: 0.0±1.1 mmHg at 25°C

Index of Refraction: 1.557

Storage condition: 2-8°C

Water Solubility: DMSO: 5 mg/mL

Specification

Appearance: White to off-whtie powder

Assay: ≥99%

Residue on ignition: ≤0.1%

Loss on drying: ≤0.5%

Application

Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt. Guggulsterone, a farnesoid X receptor (FXR) antagonist, decreases CDCA-induced FXR activation with IC50s of 17 and 15 μM for Z- and E-Guggulsterone, respectively.

Package: 25kg/drum, can also be designed according to customer requirements.

Storage: Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

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